(PDF) Cardiac Gene Therapy – Methods and Protocols by Kiyotake Ishikawa

This is the PDF eBook version for Cardiac Gene Therapy – Methods and Protocols by Kiyotake Ishikawa

Table of Contents

Part I: Overview
1. Current Methods in Cardiac Gene Therapy: Overview
Kiyotake Ishikawa and Roger J. Hajjar
Part II: Genetic Modification
2. Silencing Genes in the Heart
Henry Fechner, Roland Vetter, Jens Kurreck, and Wolfgang Poller
3. Generation of Efficient miRNA Inhibitors Using Tough Decoy Constructs
Jimeen Yoo, Roger J. Hajjar, and Dongtak Jeong
4. Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro
Vittavat Termglinchan, Timon Seeger, Caressa Chen, Joseph C. Wu, and Ioannis Karakikes
5. Direct Cardiac Reprogramming as a Novel Therapeutic Strategy for Treatment of Myocardial Infarction
Hong Ma, Li Wang, Jiandong Liu, and Li Qian
Part III: Gene Delivery Vectors
6. Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9
Erik Kohlbrenner and Thomas Weber
7. Cell-Based Measurement of Neutralizing Antibodies Against Adeno-Associated Virus (AAV)
Andreas Jungmann, Oliver Muller, and Kleopatra Rapti
8. Synthesis of Modified mRNA for Myocardial Delivery
Jason Kondrat, Nishat Sultana, and Lior Zangi
9. Exosomes-Based Gene Therapy for MicroRNA Deliver
Prabhu Mathiyalagan and Susmita Sahoo
10. Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents
Irene C. Turnbull, Ahmed A. Eltoukhy, Daniel G. Anderson, and Kevin D. Costa
Part IV: Gene Delivery Methods
11. Gene Transfer in Isolated Adult Cardiomyocytes
Kjetil Hodne, David B. Lipsett, and William E. Louch
12. Gene Transfer in Cardiomyocytes Derived from ES and iPS Cells
Francesca Stillitano, Ioannis Karakikes, and Roger J. Hajjar
13. Gene Transfer to Rodent Hearts In Vivo
Federica del Monte, Kiyotake Ishikawa, and Roger J. Hajjar
14. Ultrasound-Targeted Microbubble Destruction for Cardiac Gene Delivery
Shuyuan Chen and Paul A. Grayburn
15. A Needleless Liquid Jet Injection Delivery Approach for Cardiac Gene Therapy
Anthony S. Fargnoli, Michael G. Katz, and Charles R. Bridges
16. Cardiac Gene Delivery in Large Animal Models: Antegrade Techniques
Shin Watanabe, Lauren Leonardson, Roger J. Hajjar, and Kiyotake Ishikawa
17. Direct Myocardial Injection of Vectors
Guillaume Bonnet, Kiyotake Ishikawa, Roger J. Hajjar, and Yoshiaki Kawase
18. Selective Pressure-Regulate Retroinfusion for Gene Therapy Application in Ischemic Heart Disease
Rabea Hinkel and Christian Kupatt
19. Cardiac Gene Delivery Using Recirculating Devices
Melissa J. Byrne and David M. Kaye
20. Molecular Cardiac Surgery with Recirculating Delivery (MCARD): Procedure and Vector Transfer
Michael G. Katz, Anthony S. Fargnoli, Andrew P. Kendle, and Charles R. Bridges
Part V: Targeting Arrhythmia
21. Gene Delivery for the Generation of Bioartificial Pacemaker
Patrick K.W. Chan and Ronald A. Li
22. Gene Therapy for Post-Infarction Ventricular Tachycardia
J. Kevin Donahue
Part VI: Targeting Pulmonary Hypertension
23. MicroRNA Delivery Strategies to the Lung in a Model of Pulmonary Hypertension
Lin Deng, Andrew H. Baker, and Angela C. Bradshaw
24. Inhaled Gene Transfer for Pulmonary Circulation