(PDF) Organic Cation Transporters – Integration of Physiology by Ciarimboli

This is the PDF eBook version for Organic Cation Transporters – Integration of Physiology, Pathology, and Pharmacology by Giuliano Ciarimboli, Sophie Gautron, Eberhard Schlatter

Table of Contents

Introduction to the cellular transport of organic cations.- Functional properties of organic cation transporter OCT1, binding of substrates and inhibitors, and presumed transport mechanism.- Pharmacological and toxicological significance of the organic cation transporters OCT and MATE: Drug disposition, interaction and toxicity.- Genetic variability in organic cation transporters: pathophysiological manifestations and consequences for drug pharmacokinetics and efficacy.- Physiological and pathological regulation of transporters for organic cations.- Endocrine and metabolic regulation of transporters for organic cations.- Organic cation transporters (OCTs) as modulators of behavior and mood.- Organic cation transporters as modulators of neurodegeneration and neuroprotection.- Translational relevance of animal models for the study of organic cation transporter function.- Role of transporters for organic cations in plants for environmental cycling of pharmaceutical residues.