(eBook) Evolution-adjusted Tumor Pathophysiology by Albrecht Reichle

This is the PDF eBook version for Evolution-adjusted Tumor Pathophysiology – The Novel Language of Tumor Biology by Albrecht Reichle

Table of Contents

Preface. I Introduction.1. Communication – evolution – pathophysiology: An endogenous conjunction -Instead of an introduction. II Combined modularized therapies for metastatic tumors: Pointing to centralproblems of communication among ‘systems participators’ in tumors.2 Applied systems biology for the control of metastatic cancer: Therapeutic top-down strategy for targeting the tumors’ normativity. 3 Targeting the proangiogenic network in angiosarcomas: Biomodulatory therapy.4Long-term results of combined modularized, immune-modulatory, angiostatic, and antiinflammatory therapy in systemically pre-treated multi-systems Langerhans cell histiocytosis. 5Redirecting and modulating rationalizations of tumor-immanent normative functions in castration-resistant prostate ancer.III Social engineering: Biomodulation, either endogenously initiated or by implementation of non-normative boundary conditions.6 Non-hierarchically organized operations in malignancies: Stromal dysfunction induces hematopoetic malignancies. 7Biomodulatory therapy approaches in renal clear cell carcinoma: A perspective.8Proteome analysis identified the PPARc ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.IV The tumors’ normativity: Reconstructing and operationalizing startingpoints for an evolution theory.9 The philosophical quest of a cancer cell: Redefining existentialism. 10The tumor’s normativity: Normative structures, action norms and decision maxims as therapeutic targets for tumor therapy.11Criticizable claims for the validity of communication acts in biological systems: Therapeutic implications in cancer. V Evolution theory. 12Evolution theory: Its practical relevance for understanding tumordevelopment and specifying tumor therapy. 13 Modularity, subjectivity, intersubjectivity and normativity: Clinically applicable operative benchmarks.14 Turning upside down the mode of science to emphasize and harness the impact of environmental communicative events.VI From genome- or organ-centric to rationalization-centric systematization oftumors. 15Purposive-rational tumor therapy: Exploiting the tumor’s ‘living world’for diversifying, specifying and personalizing tumor therapy. 16 Including rationalizations of tumor-associated normative notions inpathophysiologic considerations: Communication-theoretical implications.VIIReconstruction of tumor-immanent normative functions, structures and decision maxims (hubs). 17Bridging a diagnostic and therapeutic gap: Selecting, assessing and categorizing tumor-associated normative notions. 18Personalizing tumor pathophysiology by diagnosing developmental problems in tumors with imaging techniques.19 Biologic memory: Induction by metronomically administered combined modularized therapy.VIIIThe tool of rationalizations constituting tumor-associated normativenotions:The non-genomic counterpart of the tumor genome and therefore,an important therapeutic target for diversifying palliative care. 20 Diversifying and specifying palliative care for patients with metastatic cancer by therapeutic implementation of non-normative boundary conditions. 21 Targeting a hallmark of cancer: Simultaneous inflammation and tumor control for palliative care in metastatic cancer. IX Novel clinical and pharmaceutical technology for bioengineering tumorresponse. 22Combined modularized tumor therapy – tumor biology – and prognostic factors: Bioengineering tumor response.X Objectifying the systems objects’ subjectivity in biological systems: A novel reification of the scientific picture about the ‘objective’ world. 23 The systems objects’ subjectivity as scientific object. Index.