(PDF) Cancer Vaccines – Methods and Protocols by Michael J.P. Lawman

This is the PDF eBook version for Cancer Vaccines – Methods and Protocols by Michael J.P. Lawman, Patricia D. Lawman

Table of Contents

Part I: Manipulation and Modification of Immune Cells: Dendritic Cells

1. Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules

Daphné Benteyn, An M.T. Van Nuffel, Sofie Wilgenhof, and Aude Bonehill

2. Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine

Hyun-Ju Lee, Nu-Ri Choi, Manh-Cuong Vo, My-Dung Hoang, Youn-Kyung Lee, and Je-Jung Lee

3. Pulsing Dendritic Cells with Whole Tumor Cell Lysates

Laura Alaniz, Manglio M. Rizzo, and Guillermo Mazzolini

4. Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy

Chiranjib Pal

5. Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens

Manglio M. Rizzo, Laura Alaniz, and Guillermo Mazzolini

6. Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma

Sumit K. Hira, Deepak Verma, and Partha P. Manna

7. Dendritic Cells Primed with Protein-Protein Fusion Adjuvant

Liying Wang and Yongli Yu

8. Antigen-Specific mRNA Transfection of Autologous Dendritic Cells

Fabian Benencia

9. Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material

Francesca Milano and K.K. Krishnadath

10. Dendritic Cells Transfected with Adenoviral Vectors as Vaccines

Joseph Senesac, Dmitry Gabrilovich, Samuel Pirruccello, and James E. Talmadge

11. Genetic Modification of Dendritic Cells with RNAi

Xiao-Tong Song

12. Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy

Gamal Ramadan

13. Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation

Naoshi Kawamura, Masaru Udagawa, Tomonobu Fujita, Toshiharu Sakurai, Tomonori Yaguchi, and Yutaka Kawakami

14. Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines

Roeland Lameris, Famke L. Schneiders, Tanja D. de Gruijl, and Hans J. van der Vliet

Part II: Manipulation and Modification of Immune Cells: T Lymphocytes and NK Cells

15. Modification of T Lymphocytes to Express Tumor Antigens

Aaron E. Foster and Xiao-Tong Song

16. Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor

Liza B. John, Tess M. Chee, David E. Gilham, and Phillip K. Darcy

17. Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors

Serena K. Perna, Barbara Savoldo, and Gianpietro Dotti

18. Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients

Chiara Camisaschi, Marcella Tazzari, Licia Rivoltini, and Chiara Castelli

19. Cytokine Activation of Natural Killer Cells

Syh-Jae Lin, Pei-Tzu Lee, and Ming-Ling Kuo

Part III: Manipulation and Modification of Tumor Cells

20. Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation

Eva Lion, Charlotte M. de Winde, Viggo F.I. Van Tendeloo, and Evelien L.J.M. Smits

21. Autologous Tumor Cells Engineered to Express Bacterial Antigens

Vijayakumar K. Ramiya, Maya M. Jerald, Patricia D. Lawman, and Michael J.P. Lawman

22. Tumor Cell Transformation Using Antisense Oligonucleotide

Mohamed R. Akl and Nehad M. Ayoub

23. The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy

Haval Shirwan, Esma S. Yolcu, Rajesh K. Sharma, Hong Zaho, and Orlando Grimany-Nuno

Part IV: Manipulation of Immune/Tumor Interactions

24. Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine

Soung-chul Cha, Hong Qin, Ippei Sakamaki, and Larry Kwak

25. Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography

Christian Kleist, Marco Randazzo, Janina Jiga, and Peter Terness

26. Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu

Sonia A. Perez, George E. Peoples, Michael Papamichail, and Constantin N. Baxevanis

27. TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens

Hidekazu Shirota and Dennis M. Klinman

28. Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens

Rena Morita, Yoshihiko Hirohashi, Munehide Nakatsugawa, Takayuki Kanaseki, Toshihiko Torigoe, and Noriyuki Sato

29. Preparation of Polypeptides Comprising Multiple TAA Peptides

Bing Ni, Zhengcai Jia, and Yuzhang Wu

30. Idiotype Vaccine Production Using Hybridoma Technology

Susana Inoges, Ascension Lopez-Diaz de Cerio, Helena Villanueva, Fernando Pastor, and Maurizio Bendandi

31. Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens

Reshu Gupta and Pradip P Sachdeva

Part V: Delivery Mechanisms

32. Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule

Paul M. Howley, Kerrilyn R. Diener, and John D. Hayball

33. Bacterial Vectors for the Delivery of Tumor Antigens

Yan Wang, Bertrand Toussaint, and Audrey Le Gouëllec

34. Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides

Santwana Bhatnagar, Raza Ali Naqvi, Riyasat Ali, and D.N. Rao

35. Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells

Vijaya Bharti Joshi, Sean M. Geary, and Aliasger K. Salem

36. Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection

Rama P. Kotipatruni and Ganji Purnachandra Nagaraju

Part VI: The Advances, Challenges, and Future of Cancer Vaccines

37. The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy

Mohamed L. Salem

38. Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines

Juergen Mairhofer and Alvaro R. Lara

39. Challenges Facing the Development of Cancer Vaccines

Mayer Fishman

40. Future of Cancer Vaccines

Hauke Winter, Bernard A. Fox, and Dominik Rüttinger