(PDF) TCTP, tpt1 – Remodeling Signaling from Stem Cell to Disease By Adam Telerman

This is the PDF eBook version for TCTP, tpt1 – Remodeling Signaling from Stem Cell to Disease By Adam Telerman, Robert Amson

Table of Contents

Chapter 1: Introduction: How We Encountered TCTP and Our Purpose in Studying It
1.1 The Initial Years: The Tumor Reversion Project
1.2 Learning to Work with High-Throughput Technology and the First Molecular Data
1.3 The Year 2000: Giving a Decisive Turn into the Understanding of the Tumor Reversion Program
1.4 The P53-TCTP Reciprocal Negative Feedback Loop and the Clinical Significance
1.5 Conclusion and Perspectives
References
Chapter 2: Structural Insights into TCTP and Its Interactions with Ligands and Proteins
2.1 Introduction
2.2 Sequence and Structure of TCTP
2.2.1 Description of the Structure of TCTP
2.2.2 Structural Homologues of TCTP
2.2.3 Functional Elements Within TCTP Sequence
2.2.3.1 Conserved Signatures
2.2.3.2 Functional Motifs in TCTP
TCTP Contains a Noncanonical Cell-Penetrating Peptide
TCTP Contains a Noncanonical BH3-like Domain
TCTP Contains an ADP/Cofilin Motif
2.2.3.3 Posttranslational Modifications of TCTP
2.3 Binding Properties and Structural Aspects of TCTP in Complex with Ions, Small Molecules, Carbohy
2.3.1 Calcium Binding
2.3.2 Antihistaminic Drugs and the Related Sertraline/Thioridazine
2.3.3 Peptides
2.3.4 Heme, Artemisinine, and Analogs
2.3.5 Nucleic Acids
2.3.6 Bombyx mori TCTP as a Binding Platform for Saccharides
2.4 Structural Aspects of TCTP in Complex with Proteins
2.4.1 TCTP Directly Interacts with Dozens of Proteins
2.4.2 Structural Information on Native Complexes
2.4.3 TCTP Tends to Self-associate
2.5 Conclusions
References
Chapter 3: Structure-Function Relationship of TCTP
3.1 Introduction
3.2 Conserved Functions of TCTP Across Kingdoms
3.3 Taxon-Specific Functions of TCTP
3.3.1 Fungi
3.3.2 Plants
3.3.3 Blood-Borne and Other Vertebrate Parasites
3.4 Non-cell Autonomous Functions of TCTP
3.5 Perspectives
References
Chapter 4: The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation
4.1 Introduction
4.1.1 The `Translationally Controlled Tumour Protein TCTP´: Names and History
4.1.2 Gene Structure and mRNA
4.1.3 Molecular Structure, Conservation and Interactions
4.2 Biological Functions of TCTP
4.2.1 Maintaining Cell Homoeostasis and Survival
4.2.1.1 Anti-apoptotic Activity: Discovery and Mechanisms
4.2.1.2 Involvement in Cellular Stress Responses
4.2.2 Involvement in the Cell Cycle and in Early Development
4.2.2.1 TCTP, a Microtubule Stabilising Protein at the Mitotic and the Meiotic Spindle
4.2.2.2 Roles for TCTP in Early Development
4.2.3 TCTP in Cell Growth Regulation, Protein Synthesis and Degradation
4.2.3.1 TCTP and Cell Growth Regulation
4.2.3.2 The Involvement of TCTP in Protein Synthesis
4.2.3.3 TCTP in the Regulation of Protein Degradation
4.2.4 Extracellular Functions of TCTP
4.2.4.1 TCTP as Extracellular `Signaling Molecule´ in Immune Reactions
4.2.4.2 TCTP Dimerisation and Other Extracellular Roles
4.3 Involvement of TCTP in Disease Processes
4.3.1 TCTP in Human Cancer
4.3.1.1 Overexpression of TCTP in Human Tumours
4.3.1.2 Mechanistic Involvement in Cancer Progression
4.3.1.3 TCTP as an Anticancer Target
4.3.2 Participation in Immunological Reactions
4.3.3 TCTP in Lower Animals and Parasitic Infections
4.3.3.1 TCTP in Protozoans
4.3.3.2 TCTP in Parasitic Worms
4.3.3.3 TCTP in Crustaceans and Other Waterborne Animals
4.3.3.4 TCTP in Arthropods
4.3.4 TCTP in Other (Patho)physiological Processes
4.3.4.1 Metabolic Regulation and Diabetes
4.3.4.2 Blood Circulation
4.4 Regulation of Cellular TCTP Levels
4.4.1 Cell Physiologic Conditions That Result in Regulation of TCTP Levels
4.4.2 Mechanisms Involved in Regulation of Cellular TCTP Levels
4.4.2.1 Transcriptional Regulation of TPT1 Gene Expression
4.4.2.2 Translational Regulation of TCTP Synthesis
4.4.2.3 Other Post-transcriptional Regulation
4.5 Synopsis
References
Chapter 5: Current Understanding of the TCTP Interactome
5.1 Introduction
5.2 Global Interactome Profiling Methods
5.3 The Current Knowledge of the TCTP Interactome
5.3.1 Chaperone Proteins
5.3.2 Nucleic Acid-Binding Proteins
5.3.3 Cytoskeletal Proteins
5.3.4 Other Functions
5.4 Concluding Remarks
References
Chapter 6: Role and Fate of TCTP in Protein Degradative Pathways
6.1 Introduction
6.2 TCTP as Protein Stabilizer
6.2.1 TCTP Masks the Ubiquitination Sites of Its Partners
6.2.2 TCTP Binding Leads to E3 Ligase Degradation
6.2.3 Mmi1/ScTCTP Modulates Proteasome Activity
6.3 TCTP as Degradation Inducer
6.4 TCTP Degradation
6.5 Conclusion
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References
Chapter 7: Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development
7.1 Introduction
7.2 Features of Plant TCTP Genes
7.3 TCTP Is Essential for Plant Development
7.4 Role of TCTP in Plant Signaling
7.4.1 Is TCTP a Component of the TOR Pathway?
7.4.2 Role of TCTP in Hormone Signaling
7.4.3 Response to Abiotic and Biotic Stresses
7.5 Conclusion
References
Chapter 8: Function of Translationally Controlled Tumor Protein in Organ Growth: Lessons from Drosop
8.1 Introduction
8.2 Identification of Drosophila Tctp Function in Organ Growth
8.3 Role of Tctp in TOR Signaling
8.4 Regulation of Tctp Function by 14-3-3
8.5 Effects of 14-3-3 Isoforms and Tctp on Cyclin E
8.6 Tctp Function in DNA Damage Control
8.7 Tctp in Chromatin Remodeling and Genome Stability
8.8 Concluding Remarks
References
Chapter 9: Translationally Controlled Tumor Protein (TCTP/HRF) in Animal Venoms
9.1 Introduction
9.2 Loxosceles intermedia TCTP
9.3 Other TCTPs Found in Animal Venoms
9.4 Perspectives
References
Chapter 10: Tctp in Neuronal Circuitry Assembly
10.1 Introduction
10.1.1 Features of Axon Development
10.1.2 Axonal mRNA Localization: One in Thousands
10.1.3 Axon Guidance and Cancer: Shared Features
Box 10.1 Neuronal Connectivity and Cancer Metastasis: Historical Parallels?
10.1.4 Axonal Mitochondria
10.2 TCTP in Neuronal Circuitry Assembly
10.3 Summary and Future Directions
References
Chapter 11: Elusive Role of TCTP Protein and mRNA in Cell Cycle and Cytoskeleton Regulation
11.1 TCTP and Cell Cycle
11.1.1 The Role of TCTP Protein
11.1.2 The Role of TCTP mRNA
11.2 TCTP and Cytoskeleton
11.2.1 TCTP and Microtubules
11.2.2 TCTP and Actin
11.3 Conclusions
References
Chapter 12: The Translationally Controlled Tumor Protein and the Cellular Response to Ionizing Radia
12.1 Introduction
12.2 Primary Effects of Ionizing Radiation
12.2.1 Direct and Indirect Effects of Ionizing Radiation
12.3 Endogenous and Radiation-Induced DNA Alterations
12.3.1 DNA Damage Response Pathways and DNA Damage Repair Mechanisms
12.4 TCTP and the Sensing of Genotoxic Stress
12.5 TCTP and the Repair of DNA Damage
12.6 TCTP and Control of Cell Cycle Progression Under Normal and Stress Conditions
12.7 TCTP and Cell Death
12.8 Perspective
References
Chapter 13: TCTP Has a Crucial Role in the Different Stages of Prostate Cancer Malignant Progression
13.1 TCTP Is Upregulated in Prostate Cancer
13.2 TCTP: A Promising Target in Castration-Resistant Prostate Cancer
13.2.1 TCTP Mediates Heat Shock Protein 27 Cytoprotective Function in CRPC
13.2.2 TCTP and P53 in CRPC: “Neither Can Live While the Other Survives´´
13.2.3 Development of a TCTP Antisense Oligonucleotide for Clinical Applications
13.3 Discussion
References
Chapter 14: Role of TCTP for Cellular Differentiation and Cancer Therapy
14.1 Introduction
14.1.1 TCTP in Differentiation Processes
14.2 TCTP in Cancer
14.2.1 TCTP and Tumor Reversion
14.2.2 TCTP as Antiapoptotic Protein
14.2.3 Cell Cycle Regulation of TCTP
14.2.4 TCTP Reduces Cellular Stress
14.3 TCTP for Differentiation Therapy
14.3.1 Approaches of Differentiation Therapy in General
14.3.2 Retinoids
14.3.3 Histone Deacetylase Inhibitors
14.3.4 PPAR? Agonists
14.3.5 Vitamin D
14.3.6 Differentiation Therapy with Antihistaminic Drugs
14.4 Conclusions and Perspectives
References
Chapter 15: Targeting TCTP with Sertraline and Thioridazine in Cancer Treatment
15.1 Introduction
15.2 Experimental Approach
15.3 Conclusion and Therapeutic Perspectives
References
Chapter 16: History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TC
16.1 Introduction/Cloning
16.2 Clinical Relevance of HRF/TCTP
16.3 HRF/TCTP Extracellular Functions
16.4 Other Functions of HRF/TCTP (Mainly Intracellular)
16.5 An Inducible HRF/TCTP Transgenic Mouse
16.6 The Importance of Ship-1 on HRF/TCTP Signaling
16.7 Additional Intracellular Signaling by HRF/TCTP
16.8 HRF/TCTP as a Therapeutic Target
16.9 Summary
References
Conclusion