(PDF) Targeted Drug Strategies for Cancer and Inflammation by Ann L. Jackman

This is the PDF eBook version for Targeted Drug Strategies for Cancer and Inflammation by Ann L. Jackman, Christopher P. Leamon

Table of Contents

Biological Role, Properties and Therapeutic Applications of the Reduced Folate Carrier (RFC-SLC19A1) and the Proton-Coupled Folate Transporter (PCFT-SLC46A1).- Folate Receptors and Therapeutic Applications.- Hormonal Control of Folate Receptor Genes.- Folate Receptor Targeted Radionuclide Imaging Agents.- Folate receptor targeted thymidylate synthase inhibitors.- Discovery of novel antifolate inhibitors of de novo purine nucleotide biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.- Folate-receptor targeted cancer chemotherapy.- Anti-FR antibody generation and engineering: development of new therapeutic tools.- Folate Receptor Positive Macrophages: Cellular Targets for Imaging and Therapy of Inflammatory and Autoimmune Diseases.- Targeting Activated Macrophages via a Functional Folate Receptor for Potential Treatment of Autoimmune/Inflammatory Disorders.-