This is the PDF eBook version for Store-Operated Ca² Entry (SOCE) Pathways – Emerging Signaling Concepts in Human (Patho) physiology 2nd Edition by Klaus Groschner, Wolfgang F. Graier, Christoph Romanin
Table of Contents
Part 1. SOCE – Fundamental Mechanistic Concepts.- 1. Introduction.- 2. STIM/Orai Structures: Isolated and in Complex.- 3. Orai, the Pore-Forming Subunit of the CRAC Channel.- 4. The Interactions between STIM and Orai.- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2 Entry.- 6. Regulation of STIM and Orai by Thiol Modifications.- 7. Light-operated Ca2 entry Through Engineered CRAC Channels.- 8. Ca2 Influx Channels: The Orai-STIM1-TRPC Complexes.- 9. Contribution of TRPC1 in Store-operated Ca2 Entry: Impact on Ca2 Signaling and Cell Function.- 10. Auxiliary Proteins of the STIM/Orai Complex.- Part 2.SOCE – Crosstalk between Organelle and Cellular Compartments.- 11. Introduction.- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE.- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2 Stores.- 14. The Role of Mihondria in the Activation/Maintenance of SOCE Store-operated Ca2 Entry and Mihondria.- 15. The Role of Mihondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2 Entry.- 16.The Role of Mihondria in the Activation/Maintenance of SOCE – The Contribution of Mihondrial Ca2 Uptake, Mihondrial Motility and Location to Store-operated Ca2 Entry.- 17.Tissue specificity – The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2 Signaling.- 18. Tissue specificity SOCE – Implications for Ca2 Handling in Endothelial Cells.- 19. Tissue specificity – Store-operated Ca2 Entry in Cardiac Myocytes.- Part 3. SOCE – Molecular and Cellular (Patho) Physiology.- 20. Introduction.- 21. Immunological Disorders – Regulation of Ca2 Signaling in T Lymphocytes.- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders.- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2 Handling in Platelet Dysfunction.- 24. Cardiovascular and Hemostatic Discorders – SOCE in Cardiovascular Cells – Emerging Targets for Therapeutic Intervention.- 25. Cardiac Remodelling and Disease – SOCE and TRPC Signaling in Cardiac Pathology.- 26. Cardiac Remodelling and Disease – Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2 Entry in Cardiac Function and Pathology.- 27. Neurological and Motor Disorders – Neuronal Store-operated Ca2 Signaling: An Overview and its Function.- 28. Neurological and Motor Disorders – TRPC in Skeletal Muscle.- 29. Fertility – Store-operated Ca2 Entry in Germ Cells: Role in Egg Activation.- 30. Metabolic Disorders and Cancer – Hepayte Store-operated Ca2 Channels in Non-alcoholic Fatty Liver Disease.- 31. Metabolic Disorders and Cancer – Store-operated Ca2 Entry in Cancer: Focus on IP3R-mediated Ca2 Release from Intracellular Stores and its Role in Migration and Invasion.