(PDF) Salivary Glands – Development, Adaptations and Disease By A.S. Tucker

This is the PDF eBook version for Salivary Glands – Development, Adaptations and Disease By A.S. Tucker, I. Miletich

Table of Contents

Front Matter
Frontiers of Oral Biology
Title Page
Copyright
Contents
Preface
Introduction to Salivary Glands: Structure, Function and Embryonic Development
Abstract
Salivary Glands as Multifunctional Organs
Structures and Cell Types of Adult Salivary Glands
Different Salivary Glands, in Different Locations
Control of Saliva Production
The Mouse Submandibular Gland as a Model for Vertebrate Salivary Gland Development
Early Embryonic Development of Salivary Glands: Initial Bud Formation
Forming Branches to Escape Space Constraints
Turning Solid Epithelial Chords into Hollow Tubes
Conclusions and Perspectives
Rerefrences
Salivary Gland Adaptations: Modification of the Glands for Novel Uses
Abstract
Silk Production
Nest Formation
Venom Production
Venomous Saliva in Mammals
Evolution of the Venom System in Reptiles
Interactions of Glands and Teeth in the Reptilian Venom System
Conclusions
Acknowledgement
Rerefrences
Genetic Regulation of Salivary Gland Development in Drosophila melanogaster
Abstract
Salivary Gland Invagination
Salivary Gland Lumen Elongation
Salivary Gland Migration
Axon Guidance Cues in Salivary Gland Migration
Salivary Gland Mutagenesis Screens
Conclusion
Rerefrences
Extracellular Matrix and Growth Factors in Salivary Gland Development
Abstract
Three-Dimensional Cell and Tissue Models
Collagen
Laminin
Nidogen
Epimorphin
Tenascin C
Proteoglycans
Fibronectin
Integrins
Non-Integrin ECM Receptors
Growth Factor Signaling
Proteases and Protease Inhibitors
Exogenous Matrices and Tissue Engineering
ECM Alterations in Sjögren‘s Syndrome
ECM in Salivary Neoplasms
Future Directions
Acknowledgements
Rerefrences
Lumen Formation in Salivary Gland Development
Abstract
The Histology of Lumen Formation
Creating a Space
Lining the Lumen: Cell-Cell Junctions
Tight Junctions
Adherens Junctions
Apicobasal Polarity
Future Research
Rerefrences
Epithelial Stem/Progenitor Cells in the Embryonic Mouse Submandibular Gland
Abstract
Adult Salivary Gland Stem/Progenitor Cells
Embryonic Salivary Gland Stem/Progenitor Cells
SMG Expresses TFs Involved in Embryonic Stem Cell Self-Renewal
ETS and Sox-Related Transcription Factors are Expressed in the Epithelial End Bud
SMG Epithelia Contain Basal Progenitor Cells
Influence of Mesenchyme-Produced Growth Factors on Progenitor Cell Fate Decisions
Different ES-Related Maintenance Genes Are Downregulated by FGFs
FGF7 and FGF10 Control Bud-Related Maintenance/Differentiation Genes
Basal Cells Are Regulated by TGF-ßs
Conclusion
Rerefrences
Salivary Gland Regeneration
Abstract
Clinical Need
Salivary Glands Are Highly Adaptable
Animal Models of Glandular Atrophy and Regeneration
Mechanisms of Maintaining Gland Size
Evidence for Regeneration following an Embryonic-Like Pathway
The Bioinformatics Approach to Studying Signalling Pathways in Regenerating Glands
MAPKs Signalling Pathway
Notch Signalling Pathway
Wnt Signalling Pathway
Stem Cell Therapies to Regenerate Salivary Glands
Bioengineering of Salivary Glands
Conclusions
Acknowledgements
Rerefrences
Salivary Gland Disease
Abstract
Salivary Gland Obstructive Disease
Salivary Gland Calculi
Treatment Modalities for Stone Removal
Management of Strictures
Tumours of the Salivary Glands
Incidence
Distribution by Site of Benign and Malignant Salivary Gland Tumours
Histological Tumour Types
Management
Sjögren’s Syndrome
Discussion
References
Author Index
Subject Index