(PDF) Molecular Biology of the SARS-Coronavirus by Sunil K. Lal

This is the PDF eBook version for Molecular Biology of the SARS-Coronavirus by Sunil K. Lal

Table of Contents

Part I Viral Entry

1 Cellular Entry of the SARS Coronavirus: Implications for Transmission, Pathogenicity and Antiviral Strategies Ilona Glowacka Stephanie Bertram Stefan Pöhlmann 3

2 The Cell Biology of the SARS Coronavirus Receptor, Angiotensin-Converting Enzyme 2 Daniel W. Lambert 23

3 Structural Molecular Insights into SARS Coronavirus Cellular Attachment, Entry and Morphogenesis Daniel R. Beniac Timothy F. Booth 31

Part II Structures Involved in Viral Replication and Gene Expression

4 RNA Higher-Order Structures Within the Coronavirus 5′ and 3′ Untranslated Regions and Their Roles in Viral Replication Pinghua Liu Julian Leibowitz 47

5 Programmed -1 Ribosomal Frameshifting in SARS Coronavirus Jonathan D. Dinman 63

Part III Viral Proteins

6 Expression and Functions of SARS Coronavirus Replicative Proteins Rachel Ulferts Isabelle Imbert Bruno Canard John Ziebuhr 75

7 SARS Coronavirus Replicative Enzymes: Structures and Mechanisms Isabelle Imbert Rachel Ulferts John Ziebuhr Bruno Canard 99

8 Quaternary Structure of the SARS Coronavirus Main Protease Gu-Gang Chang 115

9 The Nucleocapsid Protein of the SARS Coronavirus: Structure, Function and Therapeutic Potential Milan Surjit Sunil K. Lal 129

10 SARS Coronavirus Accessory Gene Expression and Function Scott R. Schaecher Andrew Pekosz 153

11 SARS Accessory Proteins ORF3a and 9b and Their Functional Analysis Wei Lu Ke Xu Bing Sun 167

12 Molecular and Biochemical Characterization of the SARS-CoV Accessory Proteins ORF8a, ORF8b and ORF8ab Choong-Tat Keng Yee-Joo Tan 177

Part IV Viral Pathogenesis and Host Immune Response

13 SARS Coronavirus Pathogenesis and Therapeutic Treatment Design Timothy P. Sheahan Ralph S. Baric 195

14 Modulation of Host Cell Death by SARS Coronavirus Proteins Claudia Diemer Martha Schneider Hermann M. Schätzl Sabine Gilch 231

15 SARS Coronavirus and Lung Fibrosis Wei Zuo Xingang Zhao Ye-Guang Chen 247

16 Host Immune Responses to SARS Coronavirus in Humans Chris Ka-fai Li Xiaoning Xu 259

17 The Use of Retroviral Pseudotypes for the Measurement of Antibody Responses to SARS Coronavirus Nigel James Temperton 279

18 SARS Coronavirus Spike Protein Expression in HL-CZ Human Promonocytic Cells: Monoclonal Antibody and Cellular Transcriptomic Analyses T. Narasaraju P.L. Soong J. ter Meulen J. Goudsmit Vincent T.K. Chow 289

19 Signaling Pathways of SARS-CoV In Vitro and In Vivo Tetsuya Mizutani 305

Index 323