(eBook) Drug Resistance in Leishmania Parasites By Alicia Ponte-Sucre

This is the PDF eBook version for Drug Resistance in Leishmania Parasites – Consequences, Molecular Mechanisms and Possible Treatments By Alicia Ponte-Sucre

Table of Contents

Frontmatter
Introduction: Leishmaniasis – The Biology of a Parasite
1. DETERMINANT FEATURES IN LEISHMANIASIS
Molecular Evolution and Phylogeny of Leishmania
The Role of Reservoirs: Canine Leishmaniasis
Epidemiology of Leishmaniasis in the Time of Drug Resistance
2. LEISHMANIA AND THE IMMUNE SYSTEM
The Role of the Immune System in Resistance to Infection
Vaccination as a Control Measure
Leishmania Vaccines: Past, Present, and Future
3. CHALLENGES IN THE DIAGNOSIS, TREATMENT AND CONTROL OF LEISHMANIASIS IN TIMES OF DRUG RESISTANCE
Co-infection with HIV
Visceral Leishmaniasis
American Tegumentary Leishmaniasis
4. MOLECULAR FEATURES OF DRUG-RESISTANT LEISHMANIA
Genetic Expression and Drug Resistance, the Role of Proteomics
The Role of ABC Transporters in Drug-Resistant Leishmania
Functional Analysis of Leishmania Membrane (Non-ABC) Transporters Involved in Drug Resistance
Intracellular Mechanisms of Resistance
5. PHARMACOLOGY AND CHEMOTHERAPY OF LEISHMANIASIS
Classical Versus Novel Treatment Regimens
Drug Targets, Drug Effectors, and Drug Targeting and Delivery
Mechanisms of Miltefosine Resistance in Leishmania
P-glycoprotein-like Transporters in Leishmania: A Search for Reversal Agents
6. STRATEGIES TO CIRCUMVENT DRUG RESISTANCE IN LEISHMANIA
The Relevance of Susceptibility Tests, Breakpoints, and Markers
The Concept of Fitness and Drug Resistance in Leishmania
Backmatter