(eBook) Drug Resistance in Leishmania Parasites 2nd Edition By Alicia Ponte-Sucre, Maritza Padron-Nieves

This is the PDF eBook version for Drug Resistance in Leishmania Parasites – Consequences, Molecular Mechanisms and Possible Treatments 2nd Edition By Alicia Ponte-Sucre, Maritza Padron-Nieves

Table of Contents

Prologue.- Introduction.- Part I Determinant features in Leishmaniasis.- Molecular evolution and phylogeny of Leishmania.- The role of reservoirs: canine Leishmaniasis.- Epidemiology of Leishmaniasis in the time of drug resistance.- The role of the immune system in resistance to infection.- Part II Challenges in the diagnosis, treatment and control of Leishmaniasis in the times of drug resistance.- Co-infection with HIV.- Visceral Leishmaniasis.- Tegumentary Leishmaniasis.- Antimony accounted sequel post Kala-Azar dermal Leishmaniasis.- Part III Molecular featrues of drug resistant Leishmania.- Genetic Expression and drug resistance, the role of proteomics.- The role of AMC transporters in drug-resistant Leishmania.- Functional analysis of Leishmania membrane (non AMC) transporters involved in drug resistance.- Part IV Pharmacology and chemotherapy of Leishmaniasis.- Classical vs. novel treatment regimens.- Bioinformatics in Leishmania drug design.- Leishmanis mihondria, a druggable organelle.- P-glycoprotein-like transporters in Leishmania: a search for reversal agents.- Part V Strategies to circumvent drug resistance in Leishmania.- The relevance of susceptibility tests, breakpoints and markers.- The concept of fitness in Leishmania.