(eBook) Discovering and Developing Molecules by Allen C Templeton

This is the PDF eBook version for Discovering and Developing Molecules with Optimal Drug-Like Properties by Allen C Templeton, Stephen R. Byrn, Roy J Haskell, Thomas E. Prisinzano

Table of Contents

.- 1 Developability Assessment and Risk Management During Drug Discovery

.- 2 Discovery Formulations – Approaches and Practices in Early Preclinical Development

.- 3 Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes

.- 4 Diagnosing Biopharmaceutical Limitations

.- 5 The Importance of Molecular Design Principles in Delivering High Quality Pharmaceutical Candidates

.- 6 Predictive Approaches to Establishing, Understanding, and Communicating Risk with Emphasis on Early Development

.- 7 Strategies and Methods for Drug Candidate Phase Optimization in Discovery Space

.- 8 Efficient Laboratory Methods to Assess Risk and Design Formulations

.- 9 Advanced X-ray Analytical Methods to Understand Structure, Properties and Risk

.- 10 Performance and Characterization of Amorphous Solid Dispersions: An Overview

.- 11 Hot-Melt Extrusion: The Process-Product-Performance Interplay

.- 12 Practical Considerations for Spray Dried Formulation and Process Development

.- 13 Nanosizing: “End-to-End” Formulation Strategy for Poorly-Water- Soluble Molecules

.- 14 Leveraging Solid State Form and Physiochemical Properties for Early Clinical Formulation Efforts: Opportunities and Challenges during Telcagepant Liquid Capsule Development.