(eBook) Adhesion G Protein-coupled Receptors by Tobias Langenhan

This is the PDF eBook version for Adhesion G Protein-coupled Receptors – Molecular, Physiological and Pharmacological Principles in Health and Disease by Tobias Langenhan, Torsten Schöneberg

Table of Contents

PART I. Molecular and Pharmacological Properties of Adhesion GPCRs:-Classification, Nomenclature and Structural Aspects of Adhesion GPCRs.- 7TM Domain Structure of Adhesion GPCRs.- Understanding the Structural Basis of Adhesion GPCR Functions.-Control of Adhesion GPCR Function Through Proteolytic Processing.-Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs.- Versatile Signaling Activity of Adhesion GPCRs.- Adhesion GPCR-Related Protein Networks.-The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans.- PART II: Adhesion GPCRs as Pharmakotargets in Organ Function and Development.- Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.- Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.- Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination.-Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs.- Adhesion GPCR Function in Pulmonary Development and Disease.-Adhesion GPCRs as Modulators of Immune Cell Function.-Heart Development, Angiogenesis, and Blood-Brain Barrier Function is Modulated by Adhesion GPCRs.-Adhesion GPCRs in Tumorigenesis.