(PDF) Principles of Anticancer Drug Development by Elizabeth Garrett-Mayer

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Table of Contents

Section 1:

Chapter 1: Basic Biostatistics for the Clinical Trialist
Authors: Elizabeth G. Hill and Elizabeth Garrett-Mayer

Chapter 2: Fundamental Concepts in Clinical Pharmacology
Authors: Daniel L. Gustafson and Erica L. Bradshaw-Pierce
Chapter 3: Bioanalytical Methods in Clinical Drug Development
Authors: Walter J. Loos, Peter de Bruijn, Alex Sparreboom
Section 2

Chapter 1: Preclinical Models for Anticancer Drug Development
Author: Edward Sausville

Section 3

Chapter 1: Phase I Clinical Trials with Anticancer Agents
Authors: Stephen Leong, Justin Call, Alex Adjei, Wells Messersmith

Chapter 2: Phase II Clinical Trials with Anticancer Agents
Authors: Hui Gan, J. Jack Lee, Lillian L. Siu

Chapter 3: Phase III Clinical Trials with Anticancer Agents
Authors: Wendy Parulekar and Daniel J. Sargent

Chapter 4: Pharmacokinetic Studies in Early Anticancer Drug Development
Authors: Sharyn D Baker and Alex Sparreboom

Chapter 5: Pharmacodynamic Studies in Early Phase Drug Development
Authors: D. Ross Camidge, Robert C. Doebele and Antonio Jimeno

Chapter 6: Prediction of Antitumor response
Authors: Yu Shyr and Fred R. Hirsch

Chapter 7: Imaging Studies in Anticancer Drug Development
Author: David Mankoff

Section 4

Chapter 1: Role of the US Food and Drug Administration in Cancer Drug Development
Authors: Ann T. Farrell, Ramzi N. Dagher and Richard Pazdur

Section 5

Chapter 1: Early Clinical Trials with Cytotoxic Agents
Authors: M.J.A. de Jonge and Jaap Verweij

Chapter 2: Challenges and Sucesses in Developing Effective Anti-Angiogenic Agents
Authors: Laura QM Chow and S Gail Eckhardt

Chapter 3: Targeted Therapeutics in Cancer Treatment
Authors: Colin D. Weekes and Manuel Hidalgo

Chapter 4: Cancer Chemoprevention
Authors: Christopher H. Lieu, William N. William Jr., Scott M. Lippman

Chapter 5: Combined Modality Therapy in Cancer Management
Authors: David Raben and Kyle Rusthoven

Chapter 6: Cancer Vaccines
Author: Dan Laheru

Chapter 7: Optimizing the Development of Antibodies as Treatment for Cancer
Authors: Craig P Carden, Hendrik-Tobias Arkenau and JS de Bono

Chapter 8: Oligonucleotide Therapeutics
Authors: Cy A Stein, Britta Hoehn, John Rossi
Chapter 9: Anticancer Drug Development in Pediatric Patients
Authors: Lia Gore and Margaret Macy

Chapter 10: Clinical Trials in Special Populations
Authors: S. Percy Ivy, MD; Merrill J. Egorin, MD; Chris H. Takimoto, MD, PhD; and Jeannette Y. Wick, RPh

Section 6:

Chapter 1. NCI Sponsored Clinical Trials
Author: Janet E. Dancey and Andriana Papaconstantinou