(PDF) Advances in Nucleic Acid Therapeutics by Sudhir Agrawal

This is the PDF eBook version for Advances in Nucleic Acid Therapeutics by Sudhir Agrawal, Michael J Gait

Table of Contents

History and Development of Nucleotide Analogues in Nucleic Acids Drugs; Mechanisms of Antisense Oligonucleotides; The Medicinal Chemistry of RNase H-activating Antisense Oligonucleotides; Antisense Technology: Liver Targeting and Beyond for Drug Discovery; Oligonucleotide-based Toll-like Receptor Antagonists and Therapeutic Applications; Splicing Modulation for Therapeutics; Targeting Toxic Repeats; Research and Development of Oligonucleotides Targeting MicroRNAs (miRNAs); Oligonucleotide Targeting of Long Non-coding RNAs; Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics-Pharmacodynamics Relationships of Medicinal Oligonucleotides; Liver-targeted RNAi Therapeutics: Principles and Applications; Advances and Challenges of RNAi-Based Anti-HIV Therapeutics; Nucleic Acid Innate Immune Receptors; Synthetic Agonists of Toll-like Receptors and Therapeutic Applications; Prostate-specific Membrane Antigen (PSMA) Aptamers for Prostate Cancer Imaging and Therapy; Aptamers and Clinical Applications; CRISPR-based Technologies for Genome Engineering: Properties, Current Improvements and Applications in Medicine; Therapeutic Potential of Ribozymes; Large-scale Automated Synthesis of Therapeutic Oligonucleotides: A Status Update; Preclinical and Clinical Drug-metabolism, Pharmacokinetics and Safety of Therapeutic Oligonucleotides; Subject Index