(PDF) Practical Preimplantation Genetic Diagnosis 2nd Edition by Anver Kuliev

This is the PDF eBook version for Practical Preimplantation Genetic Diagnosis 2nd Edition by Anver Kuliev

Table of Contents

Primary prevention of genetic disorders and place of preimplantation diagnosis.- Approaches to preimplantation diagnosis.- Obtaining Biopsy Material.- Polar Body Diagnosis.- Pre-embryonic Genetic Diagnosis (PEGD).- Preconception Testing for Paternally Derived Mutations by Sperm Duplication.- Development of artificial human gametes in vitro.- Embryo Biopsy.- Single cell genetic analysis.- DNA Analysis.- FISH Analysis.- Microarray analysis.- Preimplation diagnosis for single gene disorders.- Autosomal Recessive Diseases.- Autosomal Dominant Disorders.- X-linked disorders.- Homozygous or Double Heterozygous Recessive Conditions.- Conditions with No Available Direct Mutation Testing.- De Novo Mutations.- Late-onset disorders with genetic predisposition.- Inherited Predisposition to Cancer.- Alzheimer Disease.- Inherited Cardiac Diseases.- Blood Group Incompatibility.- Congenital Malformations.- Currarino Triad.- Dynamic Mutations.- Overall Experience of PGD for Mendelian Disorders.- PGD for HLA typing.- Fanconi Anemia.- World’s First PGD for HLA Typing.- Thalassemia.- Immunodeficiencies.- Preimplantation HLA Matching without PGD.- Limitations and future prospect of PGD for HLA Typing.- Practical Implications of PGD for HLA Typing.- Preimplantation diagnosis for chromosomal disorders.- First Polar Body Morphological Grading as Possible Potential Means for Preselecting Viable Oocytes.- Aneuploidy in human oocytes.- Testing for both meiosis I and meiosis II errors required for PGD of aneuploidies.- Inconsistency between Aneuploidy Types Predicted by PB1 and Detected by Cleavage Stage Testing.- Complex Errors and Aneuloidy Rescue in Female Meiosis.- Chromosome Specific Meiotic Error Origin and Its Impact on EmbryoViability.- Mitotic Errors in Cleaving Embryos in Relation to Meiosis Errors.- PCR-based aneuploidy testing in cleaving embryos.- Practical Relevance of Autosomal Monosomy Detection.- Uniparental Disomies.- Impact of PB Testing in Detection and Avoidance of Aneuploid Embryos for Transfer.- Chromosomal rearrangements.- Polar Boby Approach.- Blastomere Nuclear Conversion by Fusion with Mouse Oocytes.- Chemical Conversion Method.- Clinical outcome of preimplantation genetic diagnosis.- Safety of PGD.- Diagnostic Accuracy of PGD.- Reproductive outcome of PGD.- Controversy in Assessing Clinical Outcome of Preimplantation Aneuploidy Testing.- Reproductive Outcome Before and after PGD in Same Couples.- Possible Impact of Aneuploidy Origin.- Possible Impact of 24 Chromosome Aneuploidy Testing.- Preimplantation diagnosis and establishment of disease and individual specific human embryonic stem cell lines.- Sources for Establishing Human Embryonic Stem Cell Lines.- Human Embryonic Stem Cell Lines with Genetic Disorders.- Human Embryonic Stem Cell Lines with Chromosomal Disorders.- Genetic Disease Specific Human Embryonic Stem Cell Lines.- Development of individual specific hESC lines.- Human Embryonic Stem Cell Lines Resistant to HIV.- Progress in Study of Disease specific hESC Lines.- Social, ethical and legal aspects.