(PDF) Gene Delivery and Therapy for Neurological Disorders by Xuenong Bo

This is the PDF eBook version for Gene Delivery and Therapy for Neurological Disorders by Xuenong Bo, Joost Verhaagen

Table of Contents

1. Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

Pádraig J. Mulcahy, Christopher Binny, Bartosz Muszynski, Evangelia Karyka, and Mimoun Azzouz

2. Lentiviral Vectors for Gene Delivery to the Nervous System

Ioanna Eleftheriadou and Nicholas D. Mazarakis

3. Gene Therapy for Parkinson’s Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)

Bas Blits, Deniz Kirik, Harald Petry, and Stephen Hermening

4. Gene Delivery and Gene Therapy for Alzheimer’s Disease

Maya Woodbury, Tomomi Kiyota, and Tsuneya Ikezu

5. Gene Therapy for Huntington’s Disease

Angela Wu, Dahna M. Fong, and Deborah Young

6. Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury

Xuenong Bo and Yi Zhang

7. Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors

Nitish D. Fagoe, Ruben Eggers, Joost Verhaagen, and Matthew R.J. Mason

8. Targeted Gene Therapy for Ischemic Stroke

Fanxia Shen and Hua Su

9. Adeno-Associated Viral Gene Therapy for Retinal Disorders

Samantha R. de Silva, Michelle E. McClements, Mark W. Hankins, and Robert E. MacLaren

10. Gene Therapy for Epilepsies

En-Ju D. Lin and Matthew J. During

11. AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement

Diane Golebiowski, Allison M. Bradbury, Churl-Su Kwon, Imramsjah M.J. van der Bom, Lorelei Stoica, Aime K. Johnson, Diane U. Wilson, Heather L. Gray-Edwards, Judith A. Hudson, Jacob A. Johnson, Ashley N. Randle, Brian K. Whitlock, James L. Sartin, Anna Luisa Kühn, Matthew Gounis, Wael Asaad, Douglas R. Martin, and Miguel Sena-Esteves

12. Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice

Monir Shababi, Erkan Y. Osman, and Christian L. Lorson

13. Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?

Isabel Martins and Isaura Tavares

14. Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models

John Lynes, Carl Koschmann, Mia Wibowo, Vandana Saxena, Marianela Candolfi, Mariela A. Moreno Ayala, Maria G. Castro, and Pedro R. Lowenstein

13. Directed Evolution of Adenoviruses
Jason G. Smith

Part V Delivery Methods

14. Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling
Matthew J. Benskey and Frederic P. Manfredsson

15. MRI-Guided Delivery of Viral Vectors
Ernesto A. Salegio, John Bringas, Krystof S. Bankiewicz

16. Systemic Gene Therapy for Targeting the CNS
Sara E. Gombash and Kevin D. Foust

17. Widespread Neuronal Transduction of the Rodent CNS via Neonatal Viral Injection
Ji-Yoen Kim, Stacy D. Grunke, and Joanna L. Jankowsky

18. AAV-Mediated Gene Transfer to Dorsal Root Ganglion
Hongwei Yu, Gregory Fischer, and Quinn H. Hogan

19. Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System
Matthew J. Benskey and Frederic P. Manfredsson

20. Gene Therapy of the Peripheral Nervous System: Celiac Ganglia

21. Convection Enhanced Delivery of Recombinant Adeno-Associated Virus into the Mouse Brain
Kevin R. Nash and Marcia N. Gordon

22. Non-Viral Gene Therapy of the Nervous System: Electroporation
XueFeng Ding and Ming Fan

23. Non-Viral, Lipid-Mediated DNA and mRNA Gene Therapy of the Central Nervous System (CNS): Chemical-Based Transfection
James G. Hecker

24. Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model
Masatoshi Suzuki and Clive N. Svendsen

Part VI Gene-Therapy Based Modeling of Neurodegenerative Disorders

25. Gene Therapy Models of Alzheimer’s Disease and Other Dementias
Benjamin Combs, Andrew Kneynsberg, and Nicholas M. Kanaan

26. Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson’s Disease
D. Luke Fischer, Sara E. Gombash, Christopher J. Kemp, Frederic P. Manfredsson, Nicole K. Polinski, Megan F. Duffy, and Caryl E. Sortwell

27. Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington’s Disease
Deborah Young

Part VII Gene-Therapy for the Treatment of Neurological Disorders

28. Gene Therapy for the Treatment of Neurological Disorders: Amyotrophic Lateral Sclerosis
Zachary T. Mceachin, Anthony Donsante, and Nicholas Boulis

29. Stereotaxic Surgical Targeting of the Non-Human Primate Causate and Putamen: Gene Therapy for Huntington’s Disease
Jodi L. McBride and Randall L. Clark

30. Gene-Therapy for the Treatment of Neurological Disorders: Metabolic Disorders
Dominic J. Gessler and Guangping Gao

31. Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms
Neha Kamran, Marianela Candolfi, Gregory J. Baker, Mariela Moreno Ayala, Marta Dzaman, Pedro R. Lowenstein, and Maria G. Castro

Part VIII Clinical Trials

32. AAV2-Neurturin for Parkinson’s Disease: What Lessons Have We Learned?
Jeffrey H. Kordower