(eBook) Acute Myelogenous Leukemia – Genetics, Biology and Therapy by Lalitha Nagarajan

This is the PDF eBook version for Acute Myelogenous Leukemia – Genetics, Biology and Therapy by Lalitha Nagarajan, Zeev Estrov

Table of Contents

The Leukemia Stem Cell.- Epigenetic Mechanisms in AML – A Target for Therapy.- Chromosomal Translocations in AML: Detection and Prognostic Significance.- Chromosomal Deletions in AML.- Genes Predictive of Outcome and Novel Molecular Classification Schemes in Adult Acute Myeloid Leukemia.- Receptor Tyrosine Kinase Alterations in AML – Biology and Therapy.- Lineage-Specific Transcription Factor Aberrations in AML.- Proleukemic RUNX1 and CBF? Mutations in the Pathogenesis of Acute Leukemia.- Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological, and Clinical Features.- MicroRNAs: New Players in AML Pathogenesis.- Murine Models of Human Acute Myeloid Leukemia.- Apoptosis in Leukemias: Regulation and Therapeutic Targeting.- Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy.- Immunotherapy of AML.- Therapy of Acute Myelogenous Leukemia in Adults.